Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis

Table 4 Association of the C/T polymorphism of the TXNDC3 gene with knee osteoarthritis in Chinese and Japanese populations

Groups compared	CC versus others			TT versus others			All genotypes^a	C allele versus T allele
	OR	P	95% CI	OR	P	95% CI	P	OR	P	95% CI
Chinese study
All patients (n = 469) versus all controls (n = 486)	1.31	0.12	0.93–1.84	3.13	0.14	0.68–14.40	0.06	1.79	0.26	0.25–1.27
Female patients (n = 323) versus female controls (n = 316)	1.28	0.24	0.85–1.94	-	-	-	0.04	1.15	0.47	0.78–1.70
Male patients (n = 146) versus male controls (n = 170)	1.36	0.31	0.75–2.45	1.18	0.88	0.16–8.40	0.55	1.28	0.37	0.74–2.21
Japanese study
All patients (n = 376) versus all controls (n = 371)	1.32	0.11	0.94–1.86	0.27	0.03	0.08–0.88	0.05	1.39	0.04	1.02–1.89
Female patients (n = 327) versus female controls (n = 113)	1.11	0.68	0.67–1.85	0.23	0.08	0.04–1.22	0.22	1.20	0.43	0.76–1.89
Male patients (n = 49) versus male controls (n = 258)	2.15	0.07	0.93–4.94	0.65	0.69	0.08–5.26	0.13	2.16	0.06	0.96–4.84

^aCC, CT and TT genotypes were grouped together, and a 2 × 3 contingency table analysis was conducted. CI, confidence interval; OR, odds ratio.

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