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Table 1 The 12 air pouch membrane mRNAs most highly upregulated by MSU crystals

From: Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes

Gene

Genbank accession number

Ref.

Linear ratio: MSU/control

Function

Function(s)

    

Inflammationa

MSUb

 

PUMA-g (GPR 109/HM74)

NM 030701

[29]

64.2

+

-

Macrophage activation, prostaglandin synthesis

Hdc

AF 109137

[46]

33.8

+

±

Histamine synthesis

TREM-1

NM 021406

[15]

31.9

+

+

Expressed on activated macrophages, neutrophils

CSF3 (also known as G-CSF)

NM 007782

[47]

29.1

+

-

Granulocyte development and recruitment

Similar to MAPK phosphatase (cpg21; unpublished)

BB 442784

NA

27.9

±

-

Potentially, intracellular signal transduction, MAPK inactivation

IL-6

NM 031168

[48]

22.5

+

+

Multiple roles

PROK-2

NM 015768

[14]

21.0

+

-

Macrophage activation, hyperesthesia/pain, angiogenesis, gut motility

P-selectin

M 72332

[49]

20.1

+

-

Leucocyte, platelet adhesion to vascular endothelium

Similar to macrophage inflammatory protein 2 precursor

BB 829808

[50]

20.0

±

-

Putative neutrophil attracting chemokine

Irg1

L 38281

[16]

19.8

+

-

Induced in macrophages by LPS, mycobacteria

Dual specificity phosphatase 16

BB 121278

[51]

19.4

±

-

Potentially, intracellular signal transduction, MAPK inactivation

Mus musculus transcribed sequences (unpublished)

BB 993160

NA

18.0

-

-

Unknown

  1. aRole of target gene in inflammation in general. bRole of target gene in MSU crystal inflammation. +, known to play a role; ±, potentially involved; -, not known; CSF, colony-stimulating factor; G-CSF, granulocyte colony stimulating factor; Hdc, histidine decarboxylase; Irg, immunoresponsive gene; LRF, leukaemia/lymphoma-related factor; MAPK, mitogen-activated protein kinase; MSU, monosodium urate; NA, not applicable; PROK, prokineticin; PUMA-g, protein upregulated on macrophages activated with interferon-γ.