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Table 1 The 12 air pouch membrane mRNAs most highly upregulated by MSU crystals

From: Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes

Gene Genbank accession number Ref. Linear ratio: MSU/control Function Function(s)
     Inflammationa MSUb  
PUMA-g (GPR 109/HM74) NM 030701 [29] 64.2 + - Macrophage activation, prostaglandin synthesis
Hdc AF 109137 [46] 33.8 + ± Histamine synthesis
TREM-1 NM 021406 [15] 31.9 + + Expressed on activated macrophages, neutrophils
CSF3 (also known as G-CSF) NM 007782 [47] 29.1 + - Granulocyte development and recruitment
Similar to MAPK phosphatase (cpg21; unpublished) BB 442784 NA 27.9 ± - Potentially, intracellular signal transduction, MAPK inactivation
IL-6 NM 031168 [48] 22.5 + + Multiple roles
PROK-2 NM 015768 [14] 21.0 + - Macrophage activation, hyperesthesia/pain, angiogenesis, gut motility
P-selectin M 72332 [49] 20.1 + - Leucocyte, platelet adhesion to vascular endothelium
Similar to macrophage inflammatory protein 2 precursor BB 829808 [50] 20.0 ± - Putative neutrophil attracting chemokine
Irg1 L 38281 [16] 19.8 + - Induced in macrophages by LPS, mycobacteria
Dual specificity phosphatase 16 BB 121278 [51] 19.4 ± - Potentially, intracellular signal transduction, MAPK inactivation
Mus musculus transcribed sequences (unpublished) BB 993160 NA 18.0 - - Unknown
  1. aRole of target gene in inflammation in general. bRole of target gene in MSU crystal inflammation. +, known to play a role; ±, potentially involved; -, not known; CSF, colony-stimulating factor; G-CSF, granulocyte colony stimulating factor; Hdc, histidine decarboxylase; Irg, immunoresponsive gene; LRF, leukaemia/lymphoma-related factor; MAPK, mitogen-activated protein kinase; MSU, monosodium urate; NA, not applicable; PROK, prokineticin; PUMA-g, protein upregulated on macrophages activated with interferon-γ.