The association between disease activity and NT-proBNP in 238 patients with rheumatoid arthritis: a 10-year longitudinal study

Table 3 Cross-sectional associations at the 10-year follow-up between NT-proBNP (dependent variable) and rheumatoid arthritis disease activity, controlling for cardiovascular risk factors

	Adjusted linear regression		Multivariate linear regression
	β coefficients	P value	β coefficients	P value
Age	1.04 (1.03–1.05)	< 0.001	1.04 (1.03–1.05)	< 0.001
Male gender	0.92 (0.64–1.31)	0.64	0.76 (0.53–1.04)	0.09
Body mass index^a	0.96 (0.93–0.98)	0.001
Atherogenic index^a	0.95 (0.86–1.04)	0.25
Creatinine^a	1.02 (1.01–1.02)	0.001	1.01 (1.00–1.02)	0.04
C-reactive protein^a	1.01 (1.0–1.03)	0.06	1.02 (1.00–1.02)	0.03
RF IgM-positive^{a, b}	0.92 (0.72–1.19)	0.53
Anti-CCP-positive^{a, b}	1.14 (0.88–1.45)	0.33
Ritchie score^a	1.00 (0.99–1.01)	0.87
DAS28^a	1.05 (0.96–1.16)	0.27
HAQ^a	1.15 (0.94–1.41)	0.17
Sharp score^a	1.002 (1.00–1.01)	0.17
Disease duration^a	1.14 (1.02–1.27)	0.02	1.15 (1.03–1.27)	0.01
R² adjusted			0.38	< 0.001

^aAge- and gender-adjusted; ^bdichotomized variable. anti-CCP, anti-cyclic citrullinated peptide antibody; DAS28, disease activity score of 28 joints; HAQ, Stanford Health Assessment Questionnaire; NT-proBNP, N-terminal pro-brain natriuretic peptide; RF, rheumatoid factor; Ritchie score, Ritchie articular index; Sharp score, van der Heijde modified Sharp criteria.

ISSN: 1478-6362