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Table 7 Evoked potentials in fibromyalgia (FM)

From: Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome

Reference

Year of study

Number of FM patients

Number of Control individuals

Evoked potential

Paradigm

EP evaluated

Findings

Alanoglu and colleagues [46]

2005

34

22

Auditory

Auditory discriminated task paradigm

P300 wave

FM reduced P300 amplitude and prolonged latency. No correlation between EP findings, pain scores, and quality of life measurements

Yoldas and colleagues [47]

2003

11

10

Auditory

Auditory discriminated task paradigm

P300 wave

FM reduced P300 amplitude, but no difference in potential latency. P300 latency negatively correlated with total myalgic scores and the control point scores. P300 amplitude correlated with PPT and total myalgic scores. No correlation in amplitude or latency with depression or anxiety.

Ozgocmen and colleagues [48]

2003

13

10

Auditory

Auditory discriminated task paradigm ~before and after sertraline treatment (8 weeks)

P300 wave

no difference in potential latency at baseline. Sertraline treatment resulted in increase in potential amplitude by 8 weeks without change in latency. No correlation between EP findings, fatigue and pain scores, but correlated to total myalgic scores

  1. EP, evoked potential; PPT, pain pressure thresholds.