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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

Figure 2

Effect of diacerein and rhein on metalloprotease-13 (MMP-13) production in human osteoarthritis subchondral bone. Subchondral bone explants were incubated for 5 days with or without interleukin-1-beta (IL-1β) (5 ng/mL) and diacerein or rhein (10 or 20 μg/mL). Data are expressed as fold changes compared with IL-1β-treated control, which was assigned a value of 1. Statistical analysis was performed versus IL-1β-treated control.

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