Time | Mice | IL-6 production (pg/ml) | Lipopolysaccharidea | |||
---|---|---|---|---|---|---|
0 μg/ml HMGB1 | 0.05 μg/ml HMGB1 | 0.5 μg/ml HMGB1 | 5 μg/ml HMGB1 | |||
PHMGB1 | ||||||
24 hours | TNFα-/- | 17.0 ± 2.3 | 17.6 ± 2.2 | 17.8 ± 2.4 | 13.1 ± 4.6 | 2,460 ± 226 |
TNFα+/+ | 16.2 ± 1.9 | 15.9 ± 2.0 | 16.8 ± 3.2 | 7.3 ± 3.1 | 6,905 ± 1,763 | |
48 hours | TNFα-/- | 19.1 ± 3.0 | 20.1 ± 2.9 | 17.0 ± 1.6 | 26.3 ± 3.8 | |
TNFα+/+ | 19.8 ± 2.2 | 18.3 ± 2.2 | 14.2 ± 2.3 | 20.2 ± 3.2 | ||
RHMGB1 | ||||||
24 hours | TNFα-/- | 28 ± 16 | 304 ± 50* (314) | 2,317 ± 264 (2,271) | 146 ± 46* (130) | |
TNFα+/+ | 68 ± 11 | 602 ± 112 (558) | 3,046 ± 757 (2,504) | 344 ± 63 (359) | ||
48 hours | TNFα-/- | 213 ± 58 | 468 ± 56* (500) | 2,541 ± 258 (2,588) | 238 ± 79 (207) | |
TNFα+/+ | 263 ± 33 | 1,133 ± 202 (1,062) | 4,114 ± 941 (3,527) | 438 ± 62 (408) |