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Table 2 Alternative splice variants selected for functional testing

From: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis

  Splice variant Clone Length of ORFa Length of ECDa C-terminal novel amino acidsb
1 VEGFR1-541 018C02 541 758 LPPANSSFML PPTSFSSNYF HFLP*
2 VEGFR2-712 015F01 712 764 E*
3 VEGFR3-765 015G09 765 775 REGGPGEGQV RRPARPTIPN PGGPAPPPHP LQESTWRTPT RS*
4 Met-877 020H07 877 932 VRNALNTVLN HQLKLN*
5 Tie1-751 016G03 751 759 ERAGPTGPPG L*
6 CSF1R-306 005A06 306 512 GTPSPSLCPA *
7 c-Kit-413 002H01 413 520 SL*
8 PDGFRβ-336 007C09 336 531 RAATCGSWER WAHYNLLSCI GAGHCR*
9 FGFR1-320 022C02 320 374 GTHCNFSSRC PALATGTGGA CISRLGETQR QESWKNGLLP AWCHILPQL*
10 RAGE-387 021C06 387 342 IGETSPQALQ TLGLGCRTAQ ALISCPILAL SLTATPPLPP CTHTQASPAP PAFCQESSQA SPFFPLS*
  1. Ten alternative splice variants were selected for functional testing. aLengths of the alternative splice variant open-reading frames (ORF) and lengths of the wildtype receptor extracellular domains (ECD) are indicated by the numbers of amino acids. bNovel C-terminal amino acids of each alternative splice variant are shown. *Stop codon.