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Table 1 Genotype frequencies and RA susceptibility

From: Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis

Gene SNP Genotypes RA (n [%]) Controls (n [%]) OR (95% CI) P value
IL-13 rs1800925 TT 26 (2.9) 26 (2.8) 1.0 (0.6–1.9) 0.9
   CT 271 (29.9) 276 (29.6) 1.0 (0.8–1.3) 0.9
   CC 608 (67.2) 631 (67.6) 1.0  
  rs1295686 TT 26 (3.0) 31 (3.3) 0.9 (0.5–1.6) 0.7
   CT 251 (29.3) 283 (30.4) 0.9 (0.8–1.2) 0.6
   CC 580 (67.7) 617 (66.3) 1.0  
IL-4 rs2227284 AA 56 (6.1) 47 (4.9) 1.2 (0.8–1.9) 0.3
   AC 316 (34.6) 349 (36.7) 0.9 (0.8–1.1) 0.4
   CC 541 (59.3) 554 (58.3) 1.0  
  rs2243263 CC 8 (0.9) 6 (0.6) 1.4 (0.4–4.8) 0.6a
   GC 146 (16.4) 166 (17.9) 0.9 (0.7–1.2) 0.4
   GG 738 (82.7) 753 (81.4) 1.0  
  rs2243267 CC 18 (2.0) 17 (1.8) 1.1 (0.5–2.3) 0.8a
   CG 218 (24.0) 205 (22.2) 1.1 (0.9–1.4) 0.4
   GG 672 (74.0) 702 (76.0) 1.0  
IL-4R rs1805010 GG 198 (21.8) 200 (21.3) 1.2 (0.9–1.5) 0.2
   AG 460 (50.7) 438 (46.6) 1.3 (1.0–1.6) 0.03
   AA 250 (27.5) 301 (32.1) 1.0  
  rs1801275 AA 38 (4.2) 41 (4.3) 1.0 (0.6–1.6) 1.0
   AG 316 (34.6) 302 (32.0) 1.1 (0.9–1.4) 0.2
   GG 558 (61.2) 601 (63.7) 1.0  
  1. aFisher's exact test. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis.