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Table 1 Genotype frequencies and RA susceptibility

From: Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis

Gene

SNP

Genotypes

RA (n [%])

Controls (n [%])

OR (95% CI)

P value

IL-13

rs1800925

TT

26 (2.9)

26 (2.8)

1.0 (0.6–1.9)

0.9

  

CT

271 (29.9)

276 (29.6)

1.0 (0.8–1.3)

0.9

  

CC

608 (67.2)

631 (67.6)

1.0

 
 

rs1295686

TT

26 (3.0)

31 (3.3)

0.9 (0.5–1.6)

0.7

  

CT

251 (29.3)

283 (30.4)

0.9 (0.8–1.2)

0.6

  

CC

580 (67.7)

617 (66.3)

1.0

 

IL-4

rs2227284

AA

56 (6.1)

47 (4.9)

1.2 (0.8–1.9)

0.3

  

AC

316 (34.6)

349 (36.7)

0.9 (0.8–1.1)

0.4

  

CC

541 (59.3)

554 (58.3)

1.0

 
 

rs2243263

CC

8 (0.9)

6 (0.6)

1.4 (0.4–4.8)

0.6a

  

GC

146 (16.4)

166 (17.9)

0.9 (0.7–1.2)

0.4

  

GG

738 (82.7)

753 (81.4)

1.0

 
 

rs2243267

CC

18 (2.0)

17 (1.8)

1.1 (0.5–2.3)

0.8a

  

CG

218 (24.0)

205 (22.2)

1.1 (0.9–1.4)

0.4

  

GG

672 (74.0)

702 (76.0)

1.0

 

IL-4R

rs1805010

GG

198 (21.8)

200 (21.3)

1.2 (0.9–1.5)

0.2

  

AG

460 (50.7)

438 (46.6)

1.3 (1.0–1.6)

0.03

  

AA

250 (27.5)

301 (32.1)

1.0

 
 

rs1801275

AA

38 (4.2)

41 (4.3)

1.0 (0.6–1.6)

1.0

  

AG

316 (34.6)

302 (32.0)

1.1 (0.9–1.4)

0.2

  

GG

558 (61.2)

601 (63.7)

1.0

 
  1. aFisher's exact test. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis.