Figure 4

NF-κB in B-lymphocyte development. A simplified schematic representation of B-lymphocyte development, highlighting some of the contributions of NF-κB at various developmental checkpoints. See text for details. BAFFR, B-cell activating factor receptor; BCR, B-cell receptor; IKK, IκB kinase; NF-κB, nuclear factor-κB; RAG, recombinase-activating gene; T1, transitional 1; T2, transitional 2; TNF, tumor necrosis factor.