Normal protective HDLs | Proinflammatory HDLs |
---|---|
Reverse cholesterol transport | Impaired reverse cholesterol transport |
   ApoAI and other lipoproteins in HDLs transport cholesterol from artery walls and macrophages to other lipids and to the liver for recycling or disposal |    ApoAI and apoJ are disabled after the addition of chlorine, nitrogen, and/or oxygen |
 |    Lipoprotein synthesis is reduced by inflammation |
Antioxidant activities | Pro-oxidant activities |
   Due primarily to enzymes PON1, lecithin cholesterol acyltransferase, platelet-activating acyl hydrolase, and glutathione peroxidase |    PON1 is disabled by association with altered apoAI |
 |    Synthesis of enzymes is decreased by inflammation |
 |    Pro-oxidants serum amyloid A and ceruloplasmin are added to HDLs |
Anti-inflammatory activities | Proinflammatory activities |
   Prevent generation of oxidized LDLs and oxidation of other proinflammatory lipids |    Primarily promote oxidation of LDLs |
   Prevent endothelial cells from expressing monocyte chemotactic protein-1 and other chemoattractants |  |
   Diminish interactions between T cells and monocytes |  |