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Table 1 Histological findings of knee joints in the meniscectomized rabbit osteoarthritis model

From: Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis

Histological findings of synoviuma Meniscectomy group (n = 6) Sham group (n = 4) Normal group (n = 4)
  0 1+ 2+ 3+ 4+ 0 1+ 2+ 3+ 4+ 0 1+ 2+ 3+ 4+
H&E staining                
   Hyperplasia of synovial cell 0 0 5 1 0 1 0 3 0 0 4 0 0 0 0
   Fibrosis in connective tissue 0 0 1 5 0 0 0 1 3 0 4 0 0 0 0
   Inflammatory cell infiltration in connective tissue 4 0 1 1 0 4 0 0 0 0 4 0 0 0 0
KM1334 immunohistochemistryb                
   Positive reactions in synovial cells 0 6 0 0 0 1 3 0 0 0 3c 1 0 0 0
   Positive reactions in fibroblastic cells 0 5 1 0 0 0 4 0 0 0 4 0 0 0 0
   Positive reactions in cartilage 6c 0 0 0 0 4 0 0 0 0 4c 0 0 0 0
Cartilage degeneration scorec (mean ± standard error) 6.0 ± 0.8 0.5 ± 0.5 0.0 ± 0.0
  1. aHistological findings criteria: 0, non remarkable; 1+, very slight; 2+, slight, 3+, moderate; 4+, marked. bKM1334; an anti-FGF8 antibody. cSafranin O/fast green staining sample examined using the modified Mankin scale.