Table 1 Histological findings of knee joints in the meniscectomized rabbit osteoarthritis model
From: Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
Histological findings of synoviuma | Meniscectomy group (n = 6) | Sham group (n = 4) | Normal group (n = 4) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | 0 | 1+ | 2+ | 3+ | 4+ | 0 | 1+ | 2+ | 3+ | 4+ | 0 | 1+ | 2+ | 3+ | 4+ |
H&E staining | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Hyperplasia of synovial cell | 0 | 0 | 5 | 1 | 0 | 1 | 0 | 3 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
   Fibrosis in connective tissue | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 1 | 3 | 0 | 4 | 0 | 0 | 0 | 0 |
   Inflammatory cell infiltration in connective tissue | 4 | 0 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
KM1334 immunohistochemistryb | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Positive reactions in synovial cells | 0 | 6 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 3c | 1 | 0 | 0 | 0 |
   Positive reactions in fibroblastic cells | 0 | 5 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
   Positive reactions in cartilage | 6c | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 4c | 0 | 0 | 0 | 0 |
Cartilage degeneration scorec (mean ± standard error) | 6.0 ± 0.8 | 0.5 ± 0.5 | 0.0 ± 0.0 | ||||||||||||