Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

Table 2 Clinical and laboratory characteristics of the juvenile rheumatoid arthritis (JRA) patients characterised

Sample	Clinical features and rheumatoid factor status	Age Onset	Age History	Fibrinogen ICs (O.D.)	Anti-cit. fibrinogen IgG (O.D.)	anti-CCP^a (IU/mL)	RF^b (IU/mL)
JRA 1	Polyarthritis, RF-	2	2	0.18	0.11	21.3	11.7
JRA 4	Polyarthritis, RF+	13		0.77	1.25	841.1	127.6
JRA 8	Polyarthritis, RF+	3	16	0.53	0.43	483.2	262.6
JRA 13	Polyarthritis, RF+	13	13	0.54	1.45	255.4	274.7
JRA 17	Systemic arthritis			0.15	0.10	24.8	24.9
JRA 22	Polyarthritis, RF-	15	15	0.13	0.09	22.7	27.1
JRA 27	Polyarthritis, RF-	1	2	0.10	0.08	20.3	7.6
JRA 31	Persistent oligoarthritis			0.16	0.13	21.5	7.3
JRA 32	Polyarthritis, RF-	5	5	0.12	0.37	26.7	6.3
JRA 41	Enthesitis-related arthritis	13	14	0.14	0.08	20.8	13.1
JRA 42	Systemic arthritis	12	12	0.17	0.08	21.8	7.1
JRA 44	Polyarthritis, RF-	9	9	0.19	0.09	20.9	10.1
JRA 49	Polyarthritis, RF+	9		1.72	0.74	1275.4	295.2
JRA 51	Systemic arthritis	5	5	0.14	0.09	21.4	7.6
JRA 71	Polyarthritis, RF+		10	0.19	0.21	360.9	186.1
JRA 79	Polyarthritis, RF-	4	4	0.20	0.10	22.1	11.7
JRA 88	Polyarthritis, RF+	11	11	0.51	0.35	287.0	236.4
JRA 106	Extended oligoarthrits	1	3	0.15	0.12	22.0	10.0
JRA 110	Persistent oligoarthritis			0.15	0.10	24.9	14.6
JRA 112	Enthesitis related arthritis			0.14	0.12	22.5	15.9

^a,bMeasured with commercial kits. JRA, juvenile rheumatoid arthritis; IC, immune complex; CCP, cyclic-citrullinated peptides; RF, rheumatoid factor; O.D., optical density

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