Table 1 Effects of cytokines on macrophages/monocytes during rheumatoid arthritis
From: Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis
Cytokine | Monocyte/macrophage activation | Cytokine release | ROI release | PG release | iNOS/NO release | MHC expression | FcγRs |
|---|---|---|---|---|---|---|---|
IL-1 | ↑ | ↑ | ↑ | ↑ |  |  |  |
IL-7 | ↑ |  |  |  |  |  |  |
IL-10 | ↑/↓ | ↑ | ↓ |  | ↑ |  | ↑ |
IL-15 | ↑ or ↓ (dose dependant) |  |  |  |  |  |  |
IL-17 | ↑ | ↑ |  | ↑ | ↑ |  |  |
IL-18 | ↑ | ↑ |  |  |  |  |  |
IL-32 |  | ↑ |  | ↑ |  |  |  |
MIF | ↑ | ↑ |  |  | ↑ |  |  |
TGFβ | Early ↑, then ↓ |  |  |  |  |  |  |
TNFα | ↑ | ↑ |  | ↑ |  | ↓ | ↓ |
Type-I IFNs | ↑ |  |  |  |  | ↑ |  |