Figure 2
Inter-individual mRNA expression variances among cytokine–cytokine receptor interactions in rheumatoid arthritis (RA) compared with normal control (NC). The graph shows genes affected by significant intra-group inter-individual mRNA expression variances in RA compared with NC (P ≤ 0.05; Bonferroni/Holm corrected Brown-Forsythe version of the Levene test; labeled in red) among Kyoto Encyclopedia of Genes and Genomes (KEGG) cytokine–cytokine receptor interactions, including the respective sub-pathways (P ≤ 0.15, χ2 test; labeled in red). Cellular processes with potential influence on or relevance for RA pathogenesis (for example, inflammation, proliferation, and cell survival) are labeled in blue, and anti-inflammatory/anti-destructive processes are labeled in black.