Table 2 KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in rheumatoid arthritis (RA) compared with normal control (that is, higher variances in RA)

1

hsa04060

Cytokine–cytokine receptor interaction^a

CXCL13, IFNA8, FNAR2, IL2RG, IL4, IL8, IL13, CXCL10, IL21R, TNFRSF17, TGFBR2, CD27, TNFRSF25, ACVR1B

2

hsa04010

MAPK signaling pathway^a

CHP, AKT2, MAP3K7IP2, PLA2G2D, IKBKB, NTRK2, PRKACA, MAPK8, PRKX, TGFBR2, CACNB1, FGF18, ACVR1B

2a

hsa04010

MAPK signaling pathway^a (classical + JNK/p38 MAPK sub-pathway)

CHP, AKT2, MAP3K7IP2, PLA2G2D, IKBKB, NTRK2, PRKACA, MAPK8, PRKX, TGFBR2, CACNB1, FGF18, ACVR1B

3

hsa05212

Pancreatic cancer^a

E2F3, AKT2, IKBKB, SMAD2, MAPK8, BCL2L1, STAT1, TGFBR2, ACVR1B

4

hsa04620

Toll-like receptor signaling pathway^a

AKT2, MAP3K7IP2, IFNA8, IFNAR2, IKBKB, IL8, CXCL10, MAPK8, STAT1

5

hsa04660

T-cell receptor signaling pathway^a

CHP, AKT2, IKBKB, IL4, RHOA, PDK1, PLCG1

6

hsa04664

Fc epsilon receptor I signaling pathway^a

AKT2, PLA2G2D, IL4, IL13, PDK1, PLCG1, MAPK8

7

hsa04520

Adherens junction^a

CSNK2A1, RHOA, SMAD2, TGFBR2, ACVR1B, CDH1

8

hsa05220

Chronic myeloid leukemia^a

E2F3, IKBKB, BCL2L1, TGFBR2, ACVR1B, AKT2

9

hsa04350

TGF-β signaling pathway^a

RHOA, SMAD2, TGFBR2, ACVR1B, ZFYVE9

9a

hsa04350

TGF-β signaling pathway^a (classical TGF-β sub-pathway)

RHOA, SMAD2, TGFBR2, ACVR1B, ZFYVE9

10

hsa04210

Apoptosis^a

AKT2, IKBKB, PRKACA, BCL2L1, CHP

10a

hsa04210

Apoptosis^a (anti-apoptotic sub-complex)

AKT2, IKBKB, PRKACA, BCL2L1, CHP