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Table 3 KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in normal control (NC) compared with rheumatoid arthritis (that is, higher variances in NC)

From: Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane

 

KEGG identification number

Pathway/complex

B (E)

χ2

P value

Affected genes

1

hsa03010

Ribosomea

8 (3)

27.62

<0.01

RPL7, RPL9, RPL21, RPL27, RPL30, RPS6, RPS10, RPS12

2

hsa04110

Cell cyclea

7 (4)

13.11

<0.01

CDKN1A, E2F1, GADD45B, ATM, SKP1A, CCNA2, CDC2

3

hsa04310

Wnt signaling pathwaya

7 (5)

7.8

0.01

CACYBP, PPP2R1B, PRKACB, PSEN1, SKP1A, TBL1XR1, FZD1

4

hsa04640

Hematopoietic cell lineagea

4 (3)

4.15

0.15

CSF1, EPOR, FLT3LG, ITGA4

5

hsa05010

Alzheimer diseasea

3 (1)

13.3

<0.01

GAPDH, LRP1, PSEN1

6

hsa01510

Neurodegenerative disordersa

3 (1)

8.18

0.01

GAPDH, NR4A2, PSEN1

  1. aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; KEGG, Kyoto Encyclopedia of Genes and Genomes; Wnt, wingless-type MMTV integration site family.