Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane

Table 6 KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in rheumatoid arthritis (RA) compared with osteoarthritis (that is, higher variances in RA)

	KEGG identification number	Pathway/complex	B (E)	χ²	P value	Affected genes
1	hsa04916	Melanogenesis^a	6 (3)	6.53	0.03	ADCY2, LEF1, PRKCB1, PRKX, TCF7, WNT8B
2	hsa04662	B-cell receptor signaling pathway^a	5 (2)	9.72	0.01	MALT1, PIK3CD, PLCG2, PRKCB1, CD72
3	hsa04370	VEGF signaling pathway^a	4 (2)	4.09	0.15	PLA2G2D, PIK3CD, PLCG2, PRKCB1

^aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; KEGG, Kyoto Encyclopedia of Genes and Genomes; VEGF, vascular endothelial growth factor.

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