Figure 6From: Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximabEffect of rituximab on circulating and synovial autoantibodies and immunoglobulin. (a) Circulating levels of autoantibodies and total IgM and IgG 8 weeks after rituximab treatment are expressed as percentage of pretreatment levels. (b) Serum-normalized levels of autoantibodies and total IgM and IgG determined by enzyme-linked immunosorbent assay, or mRNA levels of IgM and IgG1 heavy constant region determined by quantitative real-time polymerase chain reaction, in synovial biopsies 8 weeks after rituximab treatment are expressed as percentage of pretreatment levels. Data are expressed as geometric mean ± 95% confidence interval (CI) of 14 subjects. Asterisks denote that 95% CI excludes 0% change (stippled line). anti-CCP, anti-cyclic citrullinated peptide; RF-IgM, rheumatoid factor of the IgM subtype.Back to article page