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Table 4 Baseline predictive factors of radiographic outcome at 10 years (univariate analysis)

From: Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study

Baseline variables

Total Sharp score at 10 years

Radiographic progression

 

p

OR (95% CI)

p

OR (95% CI)

Total Sharp score

< 0.0001

8.66 (3.72–20.15)

0.003

3.72 (1.51–9.15)

Erosion score

< 0.0001

6.00 (2.68–13.39)

< 0.0001

8.47 (2.98–24.05)

Joint narrowing score

< 0.0001

4.71 (2.14–10.34)

0.007

3.18 (1.33–7.62)

ACPA

0.002

3.91 (1.59–9.61)

< 0.0001

10.88 (4.03–29.3)

Anti-CCP antibodies

0.005

3.37 (1.40–8.11)

< 0.0001

8.62 (2.97–25.00)

IgA RF positivity

0.01

3.19 (1.28–7.91)

0.0001

5.89 (2.27–15.28)

ESR

0.01

2.55 (1.21–5.39)

0.34

1.47 (0.66–3.26)

IgA RF level

0.02

2.40 (1.10–5.21)

0.004

3.86 (1.46–10.17)

MMP3 level

0.03

2.60 (1.07–6.30)

0.003

5.00 (1.61–15.50)

Anti-perinuclear antibodies

0.03

2.28 (1.05–4.93)

0.0002

6.11 (2.22–16.77)

Swollen joint count

0.05

0.48 (0.23–1.00)

0.88

1.05 (0.47–2.33)

Morning stiffness

0.08

2.10 (0.90–4.87)

0.31

1.65 (0.61–4.42)

HLA-DRB1*01

0.08

0.49 (0.22–1.10)

0.07

0.47 (0.20–1.08)

Tender joint count

0.08

0.48 (0.21–1.10)

0.13

0.48 (0.18–1.26)

IgM RF positivity

0.10

1.95 (0.87–4.39)

0.001

4.08 (1.63–10.20)

CRP

0.19

1.63 (0.77–3.42)

0.49

1.32 (0.58–2.99)

DAS

0.26

1.52 (0.73–3.16)

0.44

1.36 (0.61–3.05)

Anti-keratin antibodies

0.32

1.46 (0.68–3.12)

0.02

2.76 (1.09–7.00)

Age

0.34

1.42 (0.67–3.00)

0.007

3.28 (1.35–7.98)

Sex

0.40

0.67 (0.27–1.69)

0.14

0.42 (0.13–1.36)

Pain on VAS

0.45

1.36 (0.60–3.07)

0.44

0.69 (0.27–1.77)

YKL 40

0.56

1.69 (0.27–10.59)

0.36

2.30 (0.36–14.66)

Anti-nuclear antibodies

0.64

0.81 (0.34–1.93)

0.79

1.13 (0.42–3.01)

Extra-articular signs

0.68

1.29 (0.37–4.50)

0.84

1.15 (0.28–4.63)

IgM RF level

0.76

1.12 (0.52–2.39)

0.01

3.05 (1.19–7.79)

Ritchie score

0.85

1.06 (0.51–2.21)

0.86

1.07 (0.48–2.38)

Anti-HSP90 antibodies

0.92

0.95 (0.37–2.43)

0.21

0.53 (0.19–1.44)

HAQ score

0.95

0.97 (0.43–2.19)

0.60

0.77 (0.30–2.00)

  1. ACPA, anti-citrullinated protein antibody; CCP, cyclic citrullinated peptide; CI, confidence interval; CRP, C-reactive protein; DAS, disease activity score; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; HLA, human leucocyte antigen; HSP90, heat shock protein 90; MMP3, matrix metalloproteinase 3; OR, odds ratio; RF, rheumatoid factor; VAS, visual analogue score.