Histomorphology of treated knee joints of STR/ORT mice. The joints were analyzed 12 weeks after the first intra-articular injection of (a), (c), (e) the control solution or (b), (d), (f) 1 mM dimethyloxaloylglycine (DMOG). In both control joints and treated joints, representative coronar sections of the (a), (b) patellofemoral joint, (c), (d) the medial knee compartment and (e), (f) the lateral knee compartment showed distinct signs of cartilage degeneration. There were no significant differences between both groups. (c), (d) Particularly, the medial femoral condyle and medial tibial plateau were affected with complete loss of the articular cartilage (asterisks) and degeneration of the meniscus (arrowheads) in both groups. P, patella; F, femur; T, tibia. Toluidine blue staining. Bar = 1 mm.