Association of chemokine and IFN scores with disease activity in SLE patients. Each symbol represents an individual patient; horizontal lines indicate median values. (a) SLE patients with a moderate-to-severe flare of disease (SLEDAI-2K score > 10) had significantly higher chemokine scores than did those without a disease flare (SLEDAI-2K score < 4) at the time of blood donation. (b) Chemokine scores were positively correlated with SLEDAI-2K. (c) Chemokine scores were significantly elevated in SLE patients with a reduced level of complement C3 (<80 mg/dl) compared with those with normal levels of C3. (d) A significantly negative correlation was observed between the chemokine score and C3 level. In addition, IFN scores were also correlated (e) positively with SLEDAI-2K and (f) negatively with C3 level. IFN, interferon; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SLEDAI-2K, SLE Disease Activity Index 2000.