Vascular involvement in rheumatic diseases: 'vascular rheumatology'

Table 2 Relevant members of the selectin, integrin, and immunoglobulin adhesion molecule superfamilies

Adhesion receptors	Ligands
Selectins
L-selectin (CD62L, LAM-1)	Sialylated carbohydrates, GlyCAM-1
E-selectin (CD62E, ELAM-1)	Sialyl-Lewis-X
P-selectin (CD62P, PADGEM)	Sialyl-Lewis-X, other carbohydrates
Integrins
β₁ integrins	Laminin, collagen, fibronectin
α₄β₁ integrins	Fibronectin, VCAM-1
β₂ integrins	ICAM-1, ICAM-2, ICAM-3, JAM-A
β₃ integrins	Vitronectin, von Willebrand factor, other matrix molecules
Immunoglobulin superfamily
ICAM-1, ICAM-3	α_Lβ₂ (LFA-1), α_Mβ₂ (Mac-1, CR3)
VCAM-1	α₄β₁, α₄β₇
CD2	LFA-3
PECAM-1 (CD31)	PECAM-1, α_Vβ₃ integrin

ELAM-1, endothelial-leukocyte adhesion molecule-1; GlyCAM-1, glycosylation-dependent cell adhesion molecule-1; ICAM, intracellular adhesion molecule; JAM-A, junctional adhesion molecule-A; LAM-1, leukocyte adhesion molecule-1; LFA, lymphocyte function-associated antigen; Mac-1, macrophage integrin; PADGEM, platelet activation-dependent granule-external membrane protein; PECAM-1, platelet-endothelial cell adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1.

ISSN: 1478-6362