From: Vascular involvement in rheumatic diseases: 'vascular rheumatology'
Mediators | Inhibitors | |
---|---|---|
Chemokines | IL-8/CXCL8, ENA-78/CXCL5, groα/CXCL1, CTAP-III/CXCL7, SDF-1/CXCL12, MCP-1/CCL2, SLC/CCL21, MPIF/CCL23, fractalkine/CX3CL1 | PF4/CXCL4, IP-10/CXCL10, Mig/CXCL9, SLC/CCL21 |
Matrix molecules | Type I collagen, fibronectin, laminin, heparin, heparan sulphate | Thrombospondin, RGD sequence |
Cell adhesion molecules | β1 and β3 integrins, E-selectin, P-selectin, CD34, VCAM-1, endoglin, PECAM-1, vascular endothelial-cadherin, Lewisy/H, MUC18 | RGD sequence (integrin ligand) |
Growth factors | VEGF, bFGF, aFGF, PDGF, EGF, IGF-I, HIF-1, TGF-βa | TGF-βa |
Cytokines | TNF-α, IL-6a, IL-15, IL-18 | IL-4, IL-6a, IFN-α, IFN-γ |
Proteases | MMPs, plasminogen activators | TIMPs, plasminogen activator inhibitors |
Others | Angiogenin, substance P, prolactin | DMARDs, infliximab, etanercept, angiostatin, endostatin |