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Table 5 Antiangiogenic targets

From: Vascular involvement in rheumatic diseases: 'vascular rheumatology'

Endogenous inhibitors Angiostatin
  Endostatin
  Thrombospondin-2
  Interleukin-4, interleukin-13
  Platelet factor-4/CXCL4 chemokine
Exogenous inhibitors Classical disease-modifying antirheumatic drugs
  Anti-tumor necrosis factor biologics
  Thalidomide
  Fumagillin analogs
  Vascular endothelial growth factor inhibitors
  Hypoxia-inducible factor heterodimer inhibitors
  Angiopoietin-1/Tie2 inhibitors
  αVβ3 integrin inhibitors
  Microtubule destabilizers (for example, paclitaxel)
  Others (for example, glitazones)