Lupus monocyte-derived dendritic cells display decreased FITC-dextran uptake. (a) Unstimulated dendritic cells (DCs) (*P = 0.003). (b) Lipopolysaccharide/TNFα-stimulated DCs (**P = 0.05). Results are expressed as the mean ± standard error of the mean. (c) Representative histogram demonstrating impaired FITC-dextran (FD) uptake by unstimulated systemic lupus erythematosus (SLE) DCs. (d) Representative histogram showing blunted FD uptake by unstimulated DCs after D-mannose preincubation. Line colors: dark blue = control, 37°C; red = SLE, 37°C; light blue = control, 4°C; light green = SLE, 4°C; black = control + D-mannose, 37°C; dark green = SLE + D-mannose, 37°C.