Figure 4

Mannose receptor expression correlation with disease activity in monocyte-derived dendritic cells. Disease activity and levels of anti-dsDNA antibody correlate with lower levels of mannose receptor (MR) and aberrant dextran uptake by lupus monocyte-derived dendritic cells. (a) Correlation between MR expression and systemic lupus erythematosus Disease Activity Index (SLEDAI) scores (*r = -0.36, P = 0.006; **r = -0.48, P = 0.002) in systemic lupus erythematosus (SLE) patients. (b) Correlation between anti-dsDNA antibodies and MR expression (*r = -0.35, P = 0.01; **r = -0.33, P = 0.04). (c) Correlation between lupus dendritic cell FITC-dextran (FD) uptake and SLEDAI scores (*r = -0. 34, P = 0.02; **r = -0.55, P = 0.001). (d) Correlation between anti-dsDNA antibody titers and FD uptake (*r = -0.29, P = 0.05; **r = -0.49, P = 0.004).