Menopause, postmenopausal hormone use and serum uric acid levels in US women – The Third National Health and Nutrition Examination Survey

Table 5 Differences in serum uric acid levels (mg/dl) among women according to age categories^a

Age category (years)	20 to 29	30 to 39	40 to 49	50 to 59	60 to 69	≥ 70	P value for trend
Participants, n	1627	1637	1203	904	987	1304	-
Unadjusted difference (95% CI)	0 (referent)	0.20 (-0.12 to 0.16)	0.12 (-0.04 to 0.28)	0.60 (0.44 to 0.75)	0.84 (0.69 to 1.00)	1.03 (0.90 to 1.16)	< 0.001
Menopause-adjusted difference (95% CI)	0 (referent)	0.00 (-0.14 to 0.14)	0.02 (-0.14 to 0.18)	0.27 (0.10 to 0.44)	0.45 (0.23 to 0.67)	0.62 (0.43 to 0.81)	< 0.001
Menopause-GFR Adjusted difference (95% CI)	0 (referent)	-0.09 (-0.25 to -0.08)	-0.13 (-0.35 to -0.10)	0.07 (-0.18 to 0.32)	0.17 (-0.18 to 0.52)	0.27 (-0.10 to 0.64)	0.19
Multivariate difference^b (95% CI)	0 (referent)	-0.23 (-0.37 to -0.08)	-0.33 (-0.53 to -0.14)	-0.22 (-0.44 to 0.00)	-0.16 (-0.46 to 0.14)	-0.06 (-0.39 to 0.27)	0.54
Multivariate difference^c (95% CI)	0 (referent)	-0.22 (-0.37 to -0.08)	-0.34 (-0.53 to -0.16)	-0.22 (-0.45 to 0.00)	-0.15 (-0.45 to 0.14)	-0.03 (-0.36 to 0.30)	0.66

^aUric acid levels are reported in milligrams per decilitre (mg/dl); to convert to μm/l, multiply by 59.48. Data are presented incorporating sample weights and adjusted for clusters and strata of the complex sample design of NHANES III. ^bAdjusted for age, smoking status, body mass index, use of postmenopausal hormone, diuretics, beta-blockers, allopurinol and uricosuric agents, hypertension and glomerular filtration rate. ^cAdditionally adjusted for intake of alcohol, total meats, seafood, dairy foods, sugar-sweetened soft drinks, coffee and total energy. CI, confidence interval.

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