Figure 3

Nodosome signalling. Ligand binding to the LRR region regulates oligomerization of the NACHT domain and homotypic interactions between CARD domains and RIP2. Ubiquitination of the IKK complex following oligomerization of RIP2 allows for nuclear translocation of NF-κB and subsequent upregulation of proinflammatory cytokines. CARD, caspase activation and recruitment; IKK, IκB kinase; LRR, leucine rich repeat; NEMO, NF-κB essential modifier; NF-κ, nuclear factor-κB; RIP, receptor-interacting protein.