Figure 4
The inflammatory cytokine production from splenic dendritic cells in response to lipopolysaccharide (LPS) in RP105-deficient mice. The dendritic cells (4 × 105) purified from the spleens of RP105+/+ and RP105-/- mice were stimulated with LPS at various concentrations for 24 hours. The supernatants were collected and the concentrations of tumor necrosis factor-alpha (TNF-α) (a), interferon-gamma (IFN-γ) (b), interleukin-6 (IL-6) (c), and interleukin-10 (IL-10) (d) were measured. Values are mean ± standard error of five experiments, using three mice per group.