Mitochondrial regulation of the apoptotic pathway is altered in disease and modulated by sirolimus treatment. Expression of mitochondrial and cytosolic components involved in apoptosis in nephritis compared with asymptomatic tissue. The thick grey oval represents the mitochondria. The horizontal double line represents the plasma membrane. Two genes (DDX20 and MLH1) known to be involved in apoptosis were not connected to the main pathway in IPA. Green colour indicates higher level of expression in disease and red colour indicates lower level of expression in disease. The names of the genes are in "nodes". The shape of the nodes is related to gene function/family membership. The lines between the nodes represent the connectivity between genes. Solid lines indicate direct protein-protein interactions. Dotted lines represent indirect interactions.