Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

Table 1 Histopathology evaluation of kidneys from NZB/W F1 hybrid female mice at 42 weeks of age

Group	Animal	Interstitial inflammation	Glomerular nephritis		Tubular dilation
Therapy			Cellularity	Membrane thickness
None	1	+2	-2	+2	+3
None	2	+3	-1	+3	+3
None	3	+2	-1	+3	+2
None	4	+3	-3	+3	+4
None	5	+3	-3	+3	+4
None	Mean	+2.6	-2	+2.8	+3.2
Sirolimus*	1	(+1)	0	+1	+1
Sirolimus	2	(+1)	0	+1	0
Sirolimus	3	(+2)	0	0	0
Sirolimus	4	0	0	0	0
Sirolimus	5	(+1)	0	0	0
Sirolimus	Mean	+1	0	+0.4	0
	p value, untreated versus treated	0.004	0.002	0.00006	0.0001

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