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Table 1 Histopathology evaluation of kidneys from NZB/W F1 hybrid female mice at 42 weeks of age

From: Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

Group Animal Interstitial inflammation Glomerular nephritis Tubular dilation
Therapy    Cellularity Membrane thickness  
None 1 +2 -2 +2 +3
None 2 +3 -1 +3 +3
None 3 +2 -1 +3 +2
None 4 +3 -3 +3 +4
None 5 +3 -3 +3 +4
None Mean +2.6 -2 +2.8 +3.2
Sirolimus* 1 (+1) 0 +1 +1
Sirolimus 2 (+1) 0 +1 0
Sirolimus 3 (+2) 0 0 0
Sirolimus 4 0 0 0 0
Sirolimus 5 (+1) 0 0 0
Sirolimus Mean +1 0 +0.4 0
  p value, untreated versus treated 0.004 0.002 0.00006 0.0001
  1. 0 = normal, 1 = slight, 2 = mild, 3 = moderate, 4 = marked, 5 = severe.
  2. * denotes focal not diffuse.