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Table 4 Multiple regression analysis with change in BMD from 0 to 24 months at the lumbar spine (L2 to L4) and femoral neck as dependent variables. All variables are adjusted for age, gender, BMI and smoking

From: Impact of low-dose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study

 

Beta

Std.Err of beta

P-level

Adj R2 value

Δ BMD L2 to L4, 0 to 24 months All patients

    

   CRP 12 months

-0.25

0.09

0.006

14 to 16%

   P1NP 12 months

-0.26

0.10

0.009

14 to 16%

   Glucocorticoid-treatment (1 = yes, 2 = no)

0.21

0.10

0.036

14 to 16%

   IGFSD, baseline

0.17

0.09

0.059

14 to 16%

Δ BMD L2 to L4, 0 to 24 months P-group

    

   Gender (1 = woman, 2 = man)

0.31

0.13

0.022

23 to 27%

   1CTP, 12 months

-0.25

0.12

0.045

23 to 27%

   IGFSD, baseline

0.43

0.12

0.001

23 to 27%

Δ BMD L2 to L4, 0 to 24 months NoP-group

    

   P1NP, 12 months

-0.37

0.11

0.001

22 to 23%

   Gender (1 = woman, 2 = man)

-0.29

0.11

0.010

22 to 23%

Δ BMD femoral neck, 0 to 24 months All patients

    

   BMI

0.31

0.08

<0.001

23%

   CRP, 12 months

-0.20

0.08

0.017

23%

   1CTP, 12 months

-0.26

0.09

0.006

23%

Δ BMD femoral neck, 0 to 24 months P-group

    

   BMI

0.37

0.14

0.010

17 to 20%

   1CTP, 12 months

-0.33

0.12

0.012

17 to 20%

Δ BMD femoral neck, 0 to 24 months NoP-group

    

   CRP, 12 months

-0.27

0.11

0.022

20 to 23%

   BMI

0.35

0.11

0.003

20 to 23%

   1CTP, 12 months

-0.26

0.13

0.050

20 to 23%

  1. BMD = bone mineral density; BMI = body mass index; CRP = C-reactive protein; 1CTP = C-terminal propeptide of type I collagen; IGFSD = insulin-like growth factor-1, standard deviation scores; P1NP = Procollagen type I N-terminal propeptide.