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Table 4 Multiple regression analysis with change in BMD from 0 to 24 months at the lumbar spine (L2 to L4) and femoral neck as dependent variables. All variables are adjusted for age, gender, BMI and smoking

From: Impact of low-dose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study

  Beta Std.Err of beta P-level Adj R2 value
Δ BMD L2 to L4, 0 to 24 months All patients     
   CRP 12 months -0.25 0.09 0.006 14 to 16%
   P1NP 12 months -0.26 0.10 0.009 14 to 16%
   Glucocorticoid-treatment (1 = yes, 2 = no) 0.21 0.10 0.036 14 to 16%
   IGFSD, baseline 0.17 0.09 0.059 14 to 16%
Δ BMD L2 to L4, 0 to 24 months P-group     
   Gender (1 = woman, 2 = man) 0.31 0.13 0.022 23 to 27%
   1CTP, 12 months -0.25 0.12 0.045 23 to 27%
   IGFSD, baseline 0.43 0.12 0.001 23 to 27%
Δ BMD L2 to L4, 0 to 24 months NoP-group     
   P1NP, 12 months -0.37 0.11 0.001 22 to 23%
   Gender (1 = woman, 2 = man) -0.29 0.11 0.010 22 to 23%
Δ BMD femoral neck, 0 to 24 months All patients     
   BMI 0.31 0.08 <0.001 23%
   CRP, 12 months -0.20 0.08 0.017 23%
   1CTP, 12 months -0.26 0.09 0.006 23%
Δ BMD femoral neck, 0 to 24 months P-group     
   BMI 0.37 0.14 0.010 17 to 20%
   1CTP, 12 months -0.33 0.12 0.012 17 to 20%
Δ BMD femoral neck, 0 to 24 months NoP-group     
   CRP, 12 months -0.27 0.11 0.022 20 to 23%
   BMI 0.35 0.11 0.003 20 to 23%
   1CTP, 12 months -0.26 0.13 0.050 20 to 23%
  1. BMD = bone mineral density; BMI = body mass index; CRP = C-reactive protein; 1CTP = C-terminal propeptide of type I collagen; IGFSD = insulin-like growth factor-1, standard deviation scores; P1NP = Procollagen type I N-terminal propeptide.