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Table 1 Average of absolute value of cartilage loss in the global, lateral and medial compartments at 6, 12, and 24 months of follow-up

From: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

  Volume (mm3) Mean thickness (mm)
  Licofelone Naproxen p-value Licofelone Naproxen p-value
Global       
   6 mo -309.7 ± 238.9 -357.8 ± 320.3 0.140 -0.043 ± 0.034 -0.051 ± 0.047 0.093
   12 mo -438.7 ± 252.9 -543.3 ± 287.3 0.0009 -0.061 ± 0.034 -0.078 ± 0.040 <0.0001
   24 mo -701.6 ± 331.9 -853.2 ± 299.0 <0.0001 -0.095 ± 0.040 -0.119 ± 0.041 <0.0001
Lateral       
   6 mo -130.8 ± 143.7 -159.4 ± 143.4 0.085 -0.038 ± 0.041 -0.046 ± 0.043 0.091
   12 mo -192.1 ± 146.1 -244.3 ± 168.2 0.004 -0.056 ± 0.041 -0.072 ± 0.049 0.002
   24 mo -290.7 ± 184.2 -368.6 ± 161.4 0.0001 -0.080 ± 0.051 -0.105 ± 0.047 <0.0001
Medial       
   6 mo -178.9 ± 157.2 -198.3 ± 214.0 0.370 -0.047 ± 0.043 -0.056 ± 0.059 0.136
   12 mo -246.6 ± 185.3 -299.0 ± 182.7 0.014 -0.064 ± 0.050 -0.084 ± 0.049 0.0006
   24 mo -410.9 ± 229.9 -484.6 ± 237.1 0.007 -0.107 ± 0.053 -0.131 ± 0.061 0.0004
  1. Values are presented as mean ± standard deviation. mo = months