Table 2 Average of percentage of cartilage loss in the global, lateral and medial compartments at 6, 12 and 24 months of follow-up
Volume (mm3) | Mean thickness (mm) | |||||
|---|---|---|---|---|---|---|
Licofelone | Naproxen | p-value | Licofelone | Naproxen | p-value | |
Global | ||||||
6 mo | -2.7 ± 1.9 | -3.0 ± 3.2 | 0.250 | -2.4 ± 1.9 | -2.8 ± 2.9 | 0.203 |
12 mo | -3.9 ± 2.0 | -4.8 ± 2.5 | 0.0002 | -3.5 ± 1.9 | -4.5 ± 2.3 | <0.0001 |
24 mo | -5.9 ± 2.2 | -7.3 ± 2.5 | <0.0001 | -5.4 ± 2.1 | -6.7 ± 2.4 | <0.0001 |
Lateral | ||||||
6 mo | -2.1 ± 2.3 | -2.6 ± 2.6 | 0.092 | -2.0 ± 2.2 | -2.4 ± 2.5 | 0.125 |
12 mo | -3.3 ± 2.4 | -4.3 ± 3.2 | 0.001 | -3.1 ± 2.1 | -4.1 ± 2.9 | 0.0006 |
24 mo | -4.7 ± 3.0 | -6.0 ± 3.0 | 0.0002 | -4.3 ± 2.7 | -5.7 ± 2.8 | <0.0001 |
Medial | ||||||
6 mo | -3.3 ± 2.9 | -3.6 ± 5.0 | 0.560 | -2.9 ± 2.7 | -3.2 ± 4.3 | 0.383 |
12 mo | -4.6 ± 3.2 | -5.6 ± 3.5 | 0.009 | -4.0 ± 3.0 | -5.1 ± 3.2 | 0.001 |
24 mo | -7.5 ± 3.7 | -8.8 ± 4.4 | 0.004 | -6.6 ± 3.3 | -8.0 ± 3.9 | 0.001 |