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Table 2 Average of percentage of cartilage loss in the global, lateral and medial compartments at 6, 12 and 24 months of follow-up

From: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

  Volume (mm3) Mean thickness (mm)
  Licofelone Naproxen p-value Licofelone Naproxen p-value
Global       
   6 mo -2.7 ± 1.9 -3.0 ± 3.2 0.250 -2.4 ± 1.9 -2.8 ± 2.9 0.203
   12 mo -3.9 ± 2.0 -4.8 ± 2.5 0.0002 -3.5 ± 1.9 -4.5 ± 2.3 <0.0001
   24 mo -5.9 ± 2.2 -7.3 ± 2.5 <0.0001 -5.4 ± 2.1 -6.7 ± 2.4 <0.0001
Lateral       
   6 mo -2.1 ± 2.3 -2.6 ± 2.6 0.092 -2.0 ± 2.2 -2.4 ± 2.5 0.125
   12 mo -3.3 ± 2.4 -4.3 ± 3.2 0.001 -3.1 ± 2.1 -4.1 ± 2.9 0.0006
   24 mo -4.7 ± 3.0 -6.0 ± 3.0 0.0002 -4.3 ± 2.7 -5.7 ± 2.8 <0.0001
Medial       
   6 mo -3.3 ± 2.9 -3.6 ± 5.0 0.560 -2.9 ± 2.7 -3.2 ± 4.3 0.383
   12 mo -4.6 ± 3.2 -5.6 ± 3.5 0.009 -4.0 ± 3.0 -5.1 ± 3.2 0.001
   24 mo -7.5 ± 3.7 -8.8 ± 4.4 0.004 -6.6 ± 3.3 -8.0 ± 3.9 0.001
  1. Values are presented as mean ± standard deviation. mo = months
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