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Table 3 Average of absolute value of cartilage loss (volume and mean thickness) in the medial central condyle and tibia at 6, 12 and 24 months of follow-up

From: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

  Volume (mm3) Mean thickness (mm)
  Licofelone Naproxen p-value Licofelone Naproxen p-value
Condyle       
   6 mo -34.0 ± 53.0 -41.3 ± 62.4 0.271 -0.040 ± 0.083 -0.061 ± 0.102 0.056
   12 mo -48.5 ± 52.4 -60.2 ± 52.0 0.053 -0.062 ± 0.085 -0.084 ± 0.082 0.020
   24 mo -91.9 ± 74.9 -102.6 ± 73.9 0.215 -0.130 ± 0.107 -0.141 ± 0.109 0.370
Tibia       
   6 mo -41.8 ± 35.9 -40.5 ± 34.5 0.755 -0.099 ± 0.090 -0.097 ± 0.090 0.815
   12 mo -55.8 ± 39.4 -68.7 ± 44.3 0.008 -0.134 ± 0.093 -0.166 ± 0.116 0.010
   24 mo -77.4 ± 45.5 -101.9 ± 55.3 <0.0001 -0.182 ± 0.100 -0.239 ± 0.134 <0.0001
  1. Values are presented as mean ± standard deviation. mo = months