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Table 4 Average of absolute value of cartilage loss (volume and mean thickness) in the lateral central condyle and tibia at 6, 12 and 24 months of follow-up

From: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

  Volume (mm3) Mean thickness (mm)
  Licofelone Naproxen p-value Licofelone Naproxen p-value
Condyle       
   6 mo -21.5 ± 44.2 -27.6 ± 40.7 0.210 -0.031 ± 0.073 -0.040 ± 0.078 0.299
   12 mo -25.5 ± 47.6 -34.6 ± 44.7 0.088 -0.039 ± 0.077 -0.055 ± 0.081 0.078
   24 mo -35.1 ± 60.9 -46.3 ± 40.0 0.062 -0.047 ± 0.096 -0.067 ± 0.072 0.040
Tibia       
   6 mo -33.3 ± 33.2 -32.8 ± 39.3 0.899 -0.091 ± 0.098 -0.090 ± 0.110 0.940
   12 mo -44.7 ± 32.2 -56.1 ± 32.9 0.003 -0.124 ± 0.094 -0.151 ± 0.095 0.013
   24 mo -71.9 ± 41.1 -85.8 ± 41.9 0.004 -0.203 ± 0.120 -0.232 ± 0.110 0.032
  1. Values are presented as mean ± standard deviation. mo = months