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Table 5 Average of absolute value of cartilage loss (volume and mean thickness) in the medial compartment stratified by the absence or presence of meniscal extrusion at 6, 12 and 24 months of follow-up

From: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

 

Volume (mm3)

Mean thickness (mm)

 

Licofelone

Naproxen

p-value

Licofelone

Naproxen

p-value

Absence of meniscal extrusion

   6 mo

-143.5 ± 126.7

-163.7 ± 211.1

0.399

-0.038 ± 0.036

-0.046 ± 0.057

0.203

   12 mo

-198.8 ± 152.1

-253.7 ± 134.6

0.007

-0.051 ± 0.042

-0.072 ± 0.036

0.0003

   24 mo

-366.2 ± 192.8

-437.2 ± 174.3

0.006

-0.096 ± 0.049

-0.118 ± 0.044

0.0006

Presence of meniscal extrusion

   6 mo

-239.9 ± 184.9

-293.8 ± 194.0

0.171

-0.062 ± 0.049

-0.082 ± 0.057

0.076

   12 mo

-329.0 ± 208.5

-423.9 ± 234.9

0.040

-0.085 ± 0.054

-0.117 ± 0.063

0.011

   24 mo

-488.0 ± 267.3

-615.2 ± 325.9

0.040

-0.128 ± 0.055

-0.166 ± 0.084

0.013

  1. Values are presented as mean ± standard deviation. mo = months