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Table 5 Average of absolute value of cartilage loss (volume and mean thickness) in the medial compartment stratified by the absence or presence of meniscal extrusion at 6, 12 and 24 months of follow-up

From: Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

  Volume (mm3) Mean thickness (mm)
  Licofelone Naproxen p-value Licofelone Naproxen p-value
Absence of meniscal extrusion
   6 mo -143.5 ± 126.7 -163.7 ± 211.1 0.399 -0.038 ± 0.036 -0.046 ± 0.057 0.203
   12 mo -198.8 ± 152.1 -253.7 ± 134.6 0.007 -0.051 ± 0.042 -0.072 ± 0.036 0.0003
   24 mo -366.2 ± 192.8 -437.2 ± 174.3 0.006 -0.096 ± 0.049 -0.118 ± 0.044 0.0006
Presence of meniscal extrusion
   6 mo -239.9 ± 184.9 -293.8 ± 194.0 0.171 -0.062 ± 0.049 -0.082 ± 0.057 0.076
   12 mo -329.0 ± 208.5 -423.9 ± 234.9 0.040 -0.085 ± 0.054 -0.117 ± 0.063 0.011
   24 mo -488.0 ± 267.3 -615.2 ± 325.9 0.040 -0.128 ± 0.055 -0.166 ± 0.084 0.013
  1. Values are presented as mean ± standard deviation. mo = months