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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis

Figure 4

Anti-IL-17 monoclonal antibody (mAb) suppresses the development of arthritis. DBA/1 mice were immunised with 25 μg of hGPI325–339, and 200 ng of pertussis toxin was injected intraperitoneally on days 0 and 2 after immunisation. 100 μg of anti-IL-17 mAb or isotype control (control) was administered intraperitoneally on day 7 (upper panel) or day 6, 8, and 10 (lower panel) after immunisation (arrow). Mean arthritis score (± standard error of the mean (SEM)) of five mice per group. Representative data of two independent experiments. * p < 0.05, ¶p < 0.01 (Mann-Whitney's U test).

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