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Table 2 Core sequences of glucose-6-phosphate isomerase (GPI) amino acids binding I-Aq

From: Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis

Peptide Amino acid residues
3–11 ALTRDPQFQ
29–37 LFDANKDRF
41–49 SLTLNTNHG
56–64 SKNLVTEDV
72–80 AKSRGVEAA
80–88 ARERMFNGE
99–107 LHVALRNRS
102–110 ALRNRSNTP
149–157 ITDVINIGI
167–175 VTEALKPYS
173–181 PYSSGGPRV
181–189 VWYVSNIDG
196–204 LAQLNPESS
201–209 PESSLFIIA
210–218 SKTFTTQET
229–237 FLQAAKDPS
230–238 LQAAKDPSA
243–251 FVALSTNTT
253–261 VKEFGIDPQ
285–293 ALHVGFDNF
319–327 LLALLGIWY
328–336 INCFGCETH
337–345 AMLPYDQYL
391–399 FYQLIHQGT
403–411 PCDFLIPVQ
407–415 LIPVQTQHP
426–434 LANFLAQTE
452–460 AGKSPEDLE
489–497 ALVAMYEHK
537–545 SHDASTNGL
540–548 ASTNGLINF
545–553 LINFIKQQR
  1. Thirty-two types of peptides were selected as core sequences from the GPI 558 amino acid sequence, which is thought to bind the binding motif. Amino acid residues that are thought to bind anchors of I-Aq are shown in bold letters.