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Table 2 Core sequences of glucose-6-phosphate isomerase (GPI) amino acids binding I-Aq

From: Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis

Peptide

Amino acid residues

3–11

ALTRDPQFQ

29–37

LFDANKDRF

41–49

SLTLNTNHG

56–64

SKNLVTEDV

72–80

AKSRGVEAA

80–88

ARERMFNGE

99–107

LHVALRNRS

102–110

ALRNRSNTP

149–157

ITDVINIGI

167–175

VTEALKPYS

173–181

PYSSGGPRV

181–189

VWYVSNIDG

196–204

LAQLNPESS

201–209

PESSLFIIA

210–218

SKTFTTQET

229–237

FLQAAKDPS

230–238

LQAAKDPSA

243–251

FVALSTNTT

253–261

VKEFGIDPQ

285–293

ALHVGFDNF

319–327

LLALLGIWY

328–336

INCFGCETH

337–345

AMLPYDQYL

391–399

FYQLIHQGT

403–411

PCDFLIPVQ

407–415

LIPVQTQHP

426–434

LANFLAQTE

452–460

AGKSPEDLE

489–497

ALVAMYEHK

537–545

SHDASTNGL

540–548

ASTNGLINF

545–553

LINFIKQQR

  1. Thirty-two types of peptides were selected as core sequences from the GPI 558 amino acid sequence, which is thought to bind the binding motif. Amino acid residues that are thought to bind anchors of I-Aq are shown in bold letters.
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Arthritis Research & Therapy

ISSN: 1478-6362

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