Sequential concentrations of plasma adrenomedullin following intra-articular adrenomedullin injection in rabbits with antigen-induced arthritis. Whole-blood samples (total 1 ml) were taken from a peripheral artery in the rabbit ear using a 22-gauge needle before and 15, 30, 60 and 120 minutes after intra-articular injection of 3 μg adrenomedullin (AM). The plasma AM concentration was measured using an immunoenzymometric assay kit (n = 6). White circles, plasma AM levels in rabbits; black circles, average plasma AM levels at each time point after intra-articular injection of 3 μg AM. Data expressed as the mean ± standard error of the mean.