Effect of adrenomedullin on the total area of the infrapatellar fat pad. The infrapatellar fat pads were sectioned longitudinally perpendicular to the patella ligament in the middle of the tissue, and the total tissue area was determined using software. Daily intra-articular injections of 3 μg adrenomedullin (AM) significantly reduced the total tissue area by 15% and 20% at day 8 and day 21, respectively. Open and closed columns represent the data at day 8 (n = 5 in each group) and day 21 (n = 3 in each group), respectively. Data expressed as the mean ± standard error of the mean. *P < 0.05 and **P < 0.01, compared with contralateral knees.