Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis

Table 4 BV-BJ CDR3 rearrangements expanded after huCollp261–273 stimulation in ERA (early rheumatoid arthritis) patients at onset and during follow up in peripheral blood and in synovial fluid

^aThe base length of each TCR rearrangement that is shared by two or more RA patients is listed in the first column, and its presence in PBMCs is indicated by '+'. ^bTCR rearrangements that belong to private repertoires are indicated by the base length for each patient. ^cPresence of an enrichment of the indicated rearrangement in T cells obtained from synovial fluid at onset of ERA. +, huColl261–273-driven detection of the indicated rearrangement; huCollp261–273, human collagen peptide 261–273; PBMC, peripheral blood mononuclear cell; RA, rheumatoid arthritis; TCR, T-cell receptor.

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