Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis

Table 6 Detection of BV11⁺ T cells specific for huCollp261–273 is associated with disease activity

Disease status	Patient	Disease stage	DAS	BV11+ cellsa
Active	OE	Onset	6.7	+
	FA	Onset	6.0	-
	AV	Onset	6.2	-
	VR	Onset	5.2	+
	ST	Onset	6.2	-
	MS	Onset	6.2	+
	OE	Relapse	6.0	+
	VR	Relapse	3.7	+
	VG	Relapse	3.7	-
	BC	Relapse	3.7	+
	RE	Relapse	4.8	+
Moderate disease activity/remission	OE		3.5	-
	VR		2.6	-
	ST		1.6	-
	MS		1.6	-
	OE		3.2	+^b
	MS		1.6	+^b
	VGC		0.46	-
	MP		1.22	-
	LM		0.9	-

^a+ presence or – absence of the huColl261–273 driven expansion of the BV11-BJ2.2 (138 bases) peak in peripheral blood mononuclear cells. ^bPatient relapsed at the following DAS control. DAS, Disease Activity Score; huCollp261–273, human collagen peptide 261–273.

ISSN: 1478-6362