Table 7 Amino acid and cDNA sequences of the shared BV11-BJ2.2 (138 bases b) and BV13b-BJ2.3 (199 bases b) TCR CDR3 region in ERA (early rheumatoid arthritis) patients

BV11-BJ2.2 (138b)

OE

C A S S E S R Y T

TGTGCCAGCAGTGAATCCCGTTATACCGG

C A S R G Q P N T

TGTGCCAGCCGCGGACAGCCAAACACCGG

C A S R G Q P N T

VR

C A S S E P R N T

TGTGCCAGCAGTGAACCTAGGAACACCGG

C A S S E P R N T

C A S S E P R N T

C A S S E P R N T

C A S S E P R N T

C A S S A V R N T

C A S S P A G N T

C A S T P S G G T

C A S S E L A D T

C A S S G R T S T

MS

C A S R G Q P N T

TGTGCCAGCCGCGGACAGCCAAACACCGG

C A S R G Q P N T

C A S R G Q P N T

C A S R G Q P N T

C A S R G Q P N T

C A S R G Q P N T

C A S R G Q P N T

C A S R G Q P N T

C A S R G Q P N T

C A S S E P R N T

C A S S E N W N T

TGTGCCAGCAGTGAACCTAGGAACACCGG

C A S T R D G H T

C A S S E N W N T

C A S S K S G L S

BC

C A S S E S F N T

TGTGCCAGCAGTGAATCGTTTAACACCGG

C A S R G Q P N T

C A S R G Q P N T

TGTGCCAGCCGCGGACAGCCAAACACCGG

C A R Q D G D H T

C A S S G L A G A

BV13bBJ2.3

OE

C A S S E A S G S T D

TGTGCCAGCAGTGAGGCTAGCGGGAGCACAGATA

(199b)

C A S S A V P G Q R D

C A S S L S G T A P D

VR

C A S S L F S G D T D

TGTGCCAGCAGTTTATTTAGCGGGGATACAGATA

C A S S L F S G D T D

C A S S L H P G P T D

C A S S T Q A A S T D

C A S S L H P G P T D

ST

C A S S R T V G D T D

TGTGCCAGCAGCCGGACTGTAGGGGACACAGATA

C A S S R T V G D T D

C A S S R T V G D T D

C A S S D V G T G R D

C A S S D V G T G R D

C A S S D V G T G R D

MS

C A S S L S G G GT D

TGTGCCAGCAGTCTCAGCGGGGGAGGGACAGATA

C A S S D P D T S T D

C A S S E S G V A T D

C A S S V L A G KA D

C A S R V T G G P E L