Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis

Table 8 Distribution of huColl261–273 specific T cells between CD45RA-enriched and CD45RA-depleted cells

Sample composition	PBMC	Total CD19^-/CD19⁺	CD19^- CD45RA enriched/CD19⁺	CD19^- CD45RA depleted/CD19⁺
CD45 isoform expression (% of CD3⁺ cells)	CD45RA⁺ 32%		CD45RA⁺: 74% CD45RO⁺: 4.2%	CD45RA⁺: 0% CD45RO⁺: 54%
Rearrangement
BV11-BJ2.2 (138 bases)	+	+	-	+
BV13-BJ2.3 (201 bases)	+	+	+	-
BV16-BJ1.6 (86 bases)	+	+	-	+
BV16-BJ2.5 (81 bases)	+	+	-	+

Shown is the presence (+) or absence (-) of the huColl261–273 driven expansion of the indicated rearrangements. huCollp261–273, human collagen peptide 261–273.

ISSN: 1478-6362