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Figure 2 | Arthritis Research & Therapy

Figure 2

From: T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis

Figure 2

Effects of therapeutic treatment with T-614 on inflammation in the CIA rats. (a) STIR magnetic resonance images of hind paws from CIA rats. The presence of soft tissue swelling (yellow arrow) and localization of bone marrow edema (yellow triangle) are highlighted. Neither paw swelling nor bone marrow edema was seen in normal rats (subpanel a). Severe soft tissue swelling and bone erosion were seen in CIA rats treated with vehicle (subpanel b). Similar damage was observed in rats treated with nimesulide (subpanel d), but much less damage was seen in rats treated with MTX (subpanel c), T-614 (subpanels e and f), and combination treatment with T-614 and MTX (subpanel g). (b) Magnetic resonance imaging score of soft tissue swelling in treated CIA rats. Data are expressed as mean ± standard error of the mean (n = 3 to 5). *P < 0.05, **P < 0.01, versus vehicle-treated arthritic rats. CIA, collagen-induced arthritis; MTX, methotrexate.

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Arthritis Research & Therapy

ISSN: 1478-6362

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