Figure 3

Effects of treatment with T-614 on structural integrity in CIA rats. (a) Macroradiographs of rat hind paws. Neither paw swelling nor joint damage was observed in normal rats (subpanel a). Severe bone matrix resorption and erosion were seen in CIA rats treated with vehicle (subpanel b). Similar damage was observed in rats treated with nimesulide (subpanel d), but the damage was much less in rats treated with MTX (subpanel c), T-614 (subpanels e and f), and both of them (subpanel g). (b) Radiologic score of bone erosion in treated CIA rats. Data are expressed as mean ± standard error of the mean (n = 3 to 5). *P < 0.05, **P < 0.01 versus the vehicle-treated rats. (c) All images were obtained using a RS-9 in Vivo Micro-CT. Neither joint damage nor bone loss was seen in normal rats (subpanel a). Severe bone matrix resorption, erosion joint, and bone loss were seen in CIA rats treated with vehicle (subpanel b). Similar bone loss was seen in rats treated with nimesulide (subpanel d) but this was much less in rats treated with MTX (subpanel c), T-614 (subpanels e and f), and the combination of T-614 and MTX (subpanel g). CIA, collagen-induced arthritis; MTX, methotrexate.