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Table 2 Variables associated with the evolution of the disease activity score from 28-joint count with three parameters (DAS28-3), the Health Assessment Questionnaire (HAQ) score, and the Larsen score in the EMECAR cohort

From: Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort

  DAS28-3 HAQ score Larsen score
  Bivariate Multivariate Bivariate Multivariate Bivariate Multivariate
Female gender 0.57 (0.36 to 0.78)*** - 0.42 (0.29 to 0.55)*** - 6.49 (1.53 to 11.45)* -
Age at baseline 0.001 (-0.006 to 0.007) - 0.004 (0 to 0.008)* 0.002 (0 to 0.004)* -0.19 (-0.34 to -0.03)* 0.009 (-0.025 to 0.043)
Age at disease onset 0.006 (-0.002 to 0.007) 0.002 (-0.002 to 0.007) 0.20 (0.016 to 0.024)*** - 0.57(0.42 to 0.73) -
Disease duration 0.004 (-0.007 to 0.015) - 0.017 (0.009 to 0.024)*** - 0.94 (0.55 to 1.34)*** -
Extra-articular rheumatoid arthritis 0.32 (0.15 to 0.4)*** 0.16 (0.04 to 0.28)* 0.22 (0.13 to 0.31)*** 0.03 (-0.02 to 0.09) 0.06 (6.35 to 11.76)*** -
Rheumatoid factor 0.19 (-0.03 to 0.41) 0.02 (-0.12 to 0.16) 0.14 (0.01 to 0.28)* 0.03 (-0.04 to 0.1) 7.96 (3.19 to 12.72)** 0.71 (-0.37 to 1.80)
Hemoglobin (g/dl) -0.29 (-0.34 to -0.25)*** -0.19(-0.23 to -0.15)*** -0.1 (-0.12 to -0.07)*** -0.03 (-0.05 to -0.01)** -0.95 (-1.61 to -0.28)** -0.04 (-0.32 to 0.25)
Hypertension 0.05 (-0.11 to 0.21) - 0.19 (0.11 to 0.27)*** 0.05 (-0.01 to 0.11) 2.74 (0.4 to 5.08)* -0.34 (-1.3 to 0.61)
Diabetes mellitus -0.01 (-0.27 to 0.24) - 0.07 (-0.08 to 0.22) - -1.87 (-6.54 to 2.8) -
Hyperlipidemia -0.14 (-0.31 to 0.03) 0.08 (-0.05 to 0.21) -0.5 (-0.14 to 0.04) - -1.44 (-4.71 to 1.84) -
Peptic ulcer 0.17 (-0.13 to 0.47) - 0.15 (0.02 to 0.28)* 0.05 (-0.03 to 0.13) 1.30 (-3.06 to 5.66) -
Myocardial ischemia -0.05 (-0.33 to 0.23) - 0.17 (-0.08 to to0.42) 0.06 (-0.09 to 0.21) -0.49 (-6.56 to 5.58) -
Heart failure 0.31 (0.04 to 0.59)* 0.06 (-0.21 to 0.33) 0.36 (0.21 to 0.50)*** - -0.74 (-7.21 to 5.72) -
Stroke 0.15 (-0.2 to 0.49) - 0.02 (-0.27 to 0.3) - -8.94 (-13.79 to -4.09)*** -
Chronic obstructive pulmonary disease -0.1 (-0.38 to 0.17) - 0.01 (-0.13 to 0.14) - 2.2 (-3.23 to 7.64) -
Neoplasm -0.29 (-0.61 to 0.03) - 0.01 (-0.12 to 0.14) - -1.96 (-9.92 to 6.01) -
Liver disease 0.11 (-0.1 to 0.33) - -0.2 (-0.11 to 0.08) - -3.63 (-9.01 to 1.76) -2.57 (-5.07 to -0.07)*
Depression 0.27 (0.09 to 0.46)** 0.12 (-0.03 to 0.26) 0.15 (0.05 to 0.25)** 0.02 (-0.05 to 0.09) -0.79 (-3.61 to 2.03) -
Body mass index 0 (-0.02 to 0.02) - 0.01 (0 to 0.02) 0 (-0.01 to 0) -0.78 (-1.16 to -0.4)*** -0.16 (-0.65 to 0.33)
DAS28-3 (each visit) - - 0.17 (0.15 to 0.19)*** 0.15 (0.13 to 0.17)*** 0.37 (-0.23 to 0.98) -
DAS28-3 (baseline) 0.62 (0.57 to 0.67)*** 0.53 (0.48 to 0.59)*** 0.24 (0.2 to 0.28)*** -0.1 (-0.13 to -0.07)*** 6.79 (5.42 to 8.15)*** 0.68 (0.26 to 1.11)**
HAQ score (each visit) - - - - 4.92 (3.61 to 6.24)*** -
HAQ score (baseline) - - 0.85 (0.82 to 0.88)*** 0.82 (0.78 to 0.86)*** - -
Larsen score (baseline) - - - - 0.97 (0.95 to 0.99)*** 0.96 (0.94 to 0.98)***
Year       
2000 Reference Reference Reference Reference Reference Reference
2001 -0.3 (-0.4 to -0.2)*** -0.23 (-0.33 to -0.13)*** 0.01 (-0.03 to 0.05) 0.04 (-0.02 to 0.09) NA NA
2002 -0.32 (-0.43 to -0.21)*** -0.27 (-0.38 to -0.15)*** 0.06 (0.01 to 0.11)* 0.07 (0.01 to 0.13)* 2.09 (1.32 to 2.86)***° 2.07 (1.1 to 3.04)***
2003 -0.47 (-0.58 to -0.36)*** -0.4 (-0.53 to -0.27)*** 0.05 (0 to 0.11) 0.11 (0.04 to 0.18)** NA NA
2004 -0.5 (-0.63 to -0.37)*** -0.43 (-0.58 to -0.28)*** 0.09 (0.03 to 0.15)** 0.15 (0.07 to 0.22) 4.18 (2.68 to 5.68)*** 4.4 (2.68 to 6.12)***
  1. Data presented as β coefficient (95% confidence interval). NA, not available. ***P < 0.001, **P < 0.01, *P < 0.05.