Table 2 Variables associated with the evolution of the disease activity score from 28-joint count with three parameters (DAS28-3), the Health Assessment Questionnaire (HAQ) score, and the Larsen score in the EMECAR cohort

Female gender

0.57 (0.36 to 0.78)***

-

0.42 (0.29 to 0.55)***

-

6.49 (1.53 to 11.45)*

-

Age at baseline

0.001 (-0.006 to 0.007)

-

0.004 (0 to 0.008)*

0.002 (0 to 0.004)*

-0.19 (-0.34 to -0.03)*

0.009 (-0.025 to 0.043)

Age at disease onset

0.006 (-0.002 to 0.007)

0.002 (-0.002 to 0.007)

0.20 (0.016 to 0.024)***

-

0.57(0.42 to 0.73)

-

Disease duration

0.004 (-0.007 to 0.015)

-

0.017 (0.009 to 0.024)***

-

0.94 (0.55 to 1.34)***

-

Extra-articular rheumatoid arthritis

0.32 (0.15 to 0.4)***

0.16 (0.04 to 0.28)*

0.22 (0.13 to 0.31)***

0.03 (-0.02 to 0.09)

0.06 (6.35 to 11.76)***

-

Rheumatoid factor

0.19 (-0.03 to 0.41)

0.02 (-0.12 to 0.16)

0.14 (0.01 to 0.28)*

0.03 (-0.04 to 0.1)

7.96 (3.19 to 12.72)**

0.71 (-0.37 to 1.80)

Hemoglobin (g/dl)

-0.29 (-0.34 to -0.25)***

-0.19(-0.23 to -0.15)***

-0.1 (-0.12 to -0.07)***

-0.03 (-0.05 to -0.01)**

-0.95 (-1.61 to -0.28)**

-0.04 (-0.32 to 0.25)

Hypertension

0.05 (-0.11 to 0.21)

-

0.19 (0.11 to 0.27)***

0.05 (-0.01 to 0.11)

2.74 (0.4 to 5.08)*

-0.34 (-1.3 to 0.61)

Diabetes mellitus

-0.01 (-0.27 to 0.24)

-

0.07 (-0.08 to 0.22)

-

-1.87 (-6.54 to 2.8)

-

Hyperlipidemia

-0.14 (-0.31 to 0.03)

0.08 (-0.05 to 0.21)

-0.5 (-0.14 to 0.04)

-

-1.44 (-4.71 to 1.84)

-

Peptic ulcer

0.17 (-0.13 to 0.47)

-

0.15 (0.02 to 0.28)*

0.05 (-0.03 to 0.13)

1.30 (-3.06 to 5.66)

-

Myocardial ischemia

-0.05 (-0.33 to 0.23)

-

0.17 (-0.08 to to0.42)

0.06 (-0.09 to 0.21)

-0.49 (-6.56 to 5.58)

-

Heart failure

0.31 (0.04 to 0.59)*

0.06 (-0.21 to 0.33)

0.36 (0.21 to 0.50)***

-

-0.74 (-7.21 to 5.72)

-

Stroke

0.15 (-0.2 to 0.49)

-

0.02 (-0.27 to 0.3)

-

-8.94 (-13.79 to -4.09)***

-

Chronic obstructive pulmonary disease

-0.1 (-0.38 to 0.17)

-

0.01 (-0.13 to 0.14)

-

2.2 (-3.23 to 7.64)

-

Neoplasm

-0.29 (-0.61 to 0.03)

-

0.01 (-0.12 to 0.14)

-

-1.96 (-9.92 to 6.01)

-

Liver disease

0.11 (-0.1 to 0.33)

-

-0.2 (-0.11 to 0.08)

-

-3.63 (-9.01 to 1.76)

-2.57 (-5.07 to -0.07)*

Depression

0.27 (0.09 to 0.46)**

0.12 (-0.03 to 0.26)

0.15 (0.05 to 0.25)**

0.02 (-0.05 to 0.09)

-0.79 (-3.61 to 2.03)

-

Body mass index

0 (-0.02 to 0.02)

-

0.01 (0 to 0.02)

0 (-0.01 to 0)

-0.78 (-1.16 to -0.4)***

-0.16 (-0.65 to 0.33)

DAS28-3 (each visit)

-

-

0.17 (0.15 to 0.19)***

0.15 (0.13 to 0.17)***

0.37 (-0.23 to 0.98)

-

DAS28-3 (baseline)

0.62 (0.57 to 0.67)***

0.53 (0.48 to 0.59)***

0.24 (0.2 to 0.28)***

-0.1 (-0.13 to -0.07)***

6.79 (5.42 to 8.15)***

0.68 (0.26 to 1.11)**

HAQ score (each visit)

-

-

-

-

4.92 (3.61 to 6.24)***

-

HAQ score (baseline)

-

-

0.85 (0.82 to 0.88)***

0.82 (0.78 to 0.86)***

-

-

Larsen score (baseline)

-

-

-

-

0.97 (0.95 to 0.99)***

0.96 (0.94 to 0.98)***

Year

∘ 2000

Reference

Reference

Reference

Reference

Reference

Reference

∘ 2001

-0.3 (-0.4 to -0.2)***

-0.23 (-0.33 to -0.13)***

0.01 (-0.03 to 0.05)

0.04 (-0.02 to 0.09)

NA

NA

∘ 2002

-0.32 (-0.43 to -0.21)***

-0.27 (-0.38 to -0.15)***

0.06 (0.01 to 0.11)*

0.07 (0.01 to 0.13)*

2.09 (1.32 to 2.86)***^°

2.07 (1.1 to 3.04)***

∘ 2003

-0.47 (-0.58 to -0.36)***

-0.4 (-0.53 to -0.27)***

0.05 (0 to 0.11)

0.11 (0.04 to 0.18)**

NA

NA

∘ 2004

-0.5 (-0.63 to -0.37)***

-0.43 (-0.58 to -0.28)***

0.09 (0.03 to 0.15)**

0.15 (0.07 to 0.22)

4.18 (2.68 to 5.68)***

4.4 (2.68 to 6.12)***