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Table 6 Transmission disequilibrium test for TLR1–TLR6 haplotypes (rs5743618–rs5743594–rs5743810)

From: No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis

  Overall population RF-positive patients Anti-CCP-positive patients
Haplotype (frequency >5%) Transmitted/untransmitted P value Transmitted/untransmitted P value Transmitted/untransmitted P value
GCC 16/12 0.45 13/8 0.28 12/9 0.51
GCT 28/31 0.7 21/27 0.39 22/26 0.56
GTC 12/11 0.83 10/7 0.47 9/7 0.62
TCC 20/21 0.88 18/20 0.75 18/19 0.87
  1. Linkage disequilibrium: TLR1_SNP1 (rs5743618) – TLR1_SNP2 (rs5743594), D' = 0.94; TLR1_SNP2 (rs5743594) – TLR6_SNP1 (rs5743810), D' = 0.5. RF, rheumatoid factor; anti-CCP, anti-cyclic citrullinated peptide.