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Table 1 Antibody classification according to structure, with examples of products that are licensed or under development

From: Antibody engineering to develop new antirheumatic therapies

mAb category

Suffix

Examples

Specificity

Reference

Chimeric

-ximab

Infliximab (Remicade®)

TNF-α

[59]

  

Rituximab (Rituxan®, Mabthera®)

CD20

[60]

Humanised

-zumab

Alemtuzumab (MabCampath®)

CD52

[18]

  

Tocilizumab (RoActemra®)

IL-6R

[61]

  

Ocrelizumab

CD20

[62]

  

Epratuzumab

CD22

[63]

  

Certolizumab pegol (PEGylated Fab fragment) (Cimzia®)

TNF-α

[64]

  

Otelixizumab (Aglycosyl)

CD3

[42]

  

Teplizumab (Fc-mutated)

CD3

[65]

  

Visilizumab (Fc-mutated)

CD3

[44]

'Fully human'

-mumab

Adalimumab (Humira®)

TNF-α

[66]

  

Ofatumumab (Humax-CD20®)

CD20

[67]

  

Belimumab (LymphoStat-B®)

BLyS

[68]

  

Golimumab

TNF-α

[69]

Fusion proteins

-cept

Etanercept (Enbrel®)

TNF-α

[70]

  

Abatacept (Orencia®)

CD80/CD86

[71]

  

Atacicept

BLyS/BAFF

[72]

  1. BAFF, B-cell activating factor; BLyS, B-lymphocyte stimulator; Fab, fragment antigen-binding; Fc, fragment crystallisable; mAb, monoclonal antibody; TNF-α, tumour necrosis factor-alpha.